PRE-TESTING AND VACCINATION

For more detailed information on vaccinations, please see the CANIBD Vaccination Guide

TB screening should be considered.

METHOD OF ADMINISTRATION

IV infusion or SC injection

LOCATION

Infusion centre or Home

DOSING

Induction:
300 mg IV wk 0, wk 2, wk 6,

then maintenance 300 mg every 8 wks OR
following at least 2 IV infusions, 108 mg SC every 2 wks

Patients who experience a disease flare or are non-responsive, a shorter infusion interval (q 4 wks) may be considered.

TIME REQUIRED

1–2 hrs for infusion
<5 min SC injection

ROUTINE MONITORING

Patients should be monitored for any new onset or worsening of neurological signs and symptoms

Liver enzymes – transaminases and bilirubin.

Annual cervical cancer screening – pap test

Annual skin exam – skin malignancies

Influenza vaccine recommended

May consider therapeutic drug monitoring (TDM) if available

Screening for osteoporosis with bone mineral density testing periodically after diagnosis