Chest X-ray TB skin test Blood work (baseline CBC, renal and liver function, HBV)
Ensure all immunizations are current. Wait at least four weeks to start following administration of live vaccination. Pneumococcal vaccination recommended for adult patients. Recommend vaccinations: HAV, HBV, HPV, and Tdap Refer to CANIBD Vaccination Guidelines for further information.10
Use with caution in patients with chronic or recurrent infection.
METHOD OF ADMINISTRATION
SC injection
LOCATION
Home Infusion centre is also available
DOSING
Adult Dosing:
Induction: 160 mg, 80 mg, 40 mg, wk 0, wk 2, wk 4, then maintenance 40 mg every 2 wks*
Patients who experience a disease flare or are non-responsive, dose escalation may be considered.
Paediatric Dosing: 13 to 17 years of age
≥ 40 kg: 160 mg at Wk 0, 80 mg at Wk 2. Maintenance dose regimen is 20 mg every other week beginning at Wk 4.
For paediatric patients who experience a disease flare or non-response, dose escalation to 40 mg every other week may be considered.
TIME REQUIRED
<15 min
ROUTINE
MONITORING
Annual cervical cancer screening – pap test Annual skin exam – skin malignancies Influenza vaccine recommended May consider therapeutic drug monitoring (TDM) if available Screening for osteoporosis with bone mineral density testing periodically after diagnosis