Advanced Therapies in Crohn's Disease

BRAND NAME / COMPANY / REIMBURSEMENT AND LOGISTICS PROGRAM (APPROVED BY HEALTH CANADA FOR IBD INDICATIONS)

Remicade®/Johnson & Johnson Innovative Medicine/BioAdvance® (CD 2003, UC 2006)
Remdantry®/Celltrion/Celltrion Connect (2014 previously Inflectra, 2025 renamed Remdantry)
Renflexis®/Organon/Harmony by Organon™ (2018)
Avsola®/Amgen/Entrust (2025)
Remsima™/Celltrion/Celltrion Connect™ (2024)
Ixifi®/Pfizer/PfizerFlex (2024)

CLASS

Monoclonal antibody
Tumour necrosis factor (TNF) blocking agent

ACTION

IBD causes the immune system to produce an excess amount of TNFα, which causes inflammation. Anti-TNFα is a protein that works to bind TNFα and block inflammation.