Advanced Therapies in Crohn's Disease

Side Effects

Edit Content

SIDE EFFECTS

For more detailed information regarding side effects, please refer to the appropriate product monograph.

  • Infusion-related reactions – sometimes can be managed with pre-medications, IV fluids, or lengthening infusion duration.
  • Increased risk of serious infection (sepsis and pneumonia), invasive fungal infections and viral infections; approximately 10% increased risk at wk 54. Reactivation of latent TB.
  • Can worsen pre-existing CHF.
  • Lupus-like reaction (rare).
  • Anti-TNF–induced psoriasis and eczema.
  • Hepatocellular damage, hepatitis, jaundice, autoimmune hepatitis; reactivation of HBV.
  • Potential increased risk of malignancy (lymphoma, hepatosplenic T-cell lymphoma, melanoma, and NMSC); increased frequency when used in combination with a thiopurine.
  • Demyelinating disease – numbness and tingling in legs, arms, etc.
  • Change in vision, weakness in legs, dizziness.
           
Edit Content

SIDE EFFECTS

For more detailed information regarding side effects, please refer to the appropriate product monograph.

  • Infusion-related reactions – sometimes can be managed with pre-medications, IV fluids, or lengthening infusion duration.
  • Increased risk of serious infection (sepsis and pneumonia), invasive fungal infections and viral infections; approximately 10% increased risk at wk 54. Reactivation of latent TB.
  • Can worsen pre-existing CHF.
  • Lupus-like reaction (rare).
  • Anti-TNF–induced psoriasis and eczema.
  • Hepatocellular damage, hepatitis, jaundice, autoimmune hepatitis; reactivation of HBV.
  • Potential increased risk of malignancy (lymphoma, hepatosplenic T-cell lymphoma, melanoma, and NMSC); increased frequency when used in combination with a thiopurine.
  • Demyelinating disease – numbness and tingling in legs, arms, etc.
  • Change in vision, weakness in legs, dizziness.
           
Edit Content

SIDE EFFECTS

For more detailed information regarding side effects, please refer to the appropriate product monograph.

  • Injection-site reactions
  • Headaches
  • Diarrhea
  • Skin rash or itching
  • Possible infusion reaction
           
Edit Content

SIDE EFFECTS

For more detailed information regarding side effects, please refer to the appropriate product monograph.

  • Nasopharyngitis
  • Arthralgia
  • Headache
  • Nausea
  • Pyrexia
  • Upper respiratory tract infection
  • Fatigue
  • Malignancy
  • Elevated transaminase has been reported
  • No serious infections
           
Edit Content

SIDE EFFECTS

For more detailed information regarding side effects, please refer to the appropriate product monograph.

  • Fatigue
  • Upper respiratory infections
  • Headache
  • Arthralgia
  • Injection-site reaction
  • Elevated liver enzymes reported during induction
           
Edit Content

SIDE EFFECTS

For more detailed information regarding side effects, please refer to the appropriate product monograph.

  • Nasopharyngitis
  • Opportunistic infections
  • Upper respiratory tract infections
  • Herpes zoster
  • CPK elevation
  • Liver enzyme increase
  • Neutropenia
           

IV: intravenous, wk: week, TB: tuberculosis, CHF: congestive heart failure, Anti-TNF: Anti-tumour necrosis factor, HBV: hepatitis B virus, NMSC: non-melanoma skin cancer, CPK: Creatine phosphokinase

This tool is intended for Canadian Healthcare Professionals. Copyright © 2024 CANIBD Canadian IBD Nurses.

Contact Us    Provider Resources     References

CANIBD and Crohn's and Colitis Canada do not accept any responsibility or liability for the accuracy, content, completeness, legality, or reliability of the information contained in this Service. The content is not intended to diagnose, treat, cure or prevent disease. Content was developed in 2024 and is provided for informational purposes only.