Advanced Therapies in Crohn's Disease
TB screening should be considered.
Recommend all immunizations are current.
IV infusion or SC injection
Infusion centre or Home
Induction:
300 mg IV wk 0, wk 2, wk 6
Then maintenance 300 mg IV every 8 wks
OR
Following at least 2 IV infusions, 108 mg SC every 2 wks†
Patients who experience a disease flare or are non-responsive, a shorter infusion interval (q 4 wks) may be considered.
1–2 hrs for infusion
<5 min SC injection
Patients should be monitored for any new onset or worsening of neurological signs and symptoms
Liver enzymes – transaminases and bilirubin.
Cervical cancer screening – pap test as per provincial guidelines
Annual skin exam – skin malignancies
Influenza vaccine recommended
May consider therapeutic drug monitoring (TDM) if available
Screening for osteoporosis with bone mineral density testing periodically after diagnosis