Advanced Therapies in Crohn's Disease

PRE-TESTING AND VACCINATION

For more detailed information on vaccinations, please see the CANIBD Vaccination Guide12

TB skin test, blood work (baseline CBC, liver enzymes, lipids, CK, renal function, Hepatitis B serology)

Shingrix zoster, recommend receiving live vaccines prior to starting therapy.

Recommend all immunizations are current.

METHOD OF ADMINISTRATION

Oral

LOCATION

Home

DOSING

Induction:
45mg once daily for 12 wks

Then maintenance 15mg or 30mg once daily.

TIME REQUIRED

5 mins 

ROUTINE MONITORING

Baseline blood work – CBC

Liver enzymes, lipids, CK, renal function and Hepatitis B serology

Blood work q 3 months

Including CBC, liver enzymes, lipids, CK, and renal function

Cervical cancer screening – pap test as per provincial guidelines

Annual skin exam – skin malignancies

Influenza vaccine recommended

May consider therapeutic drug monitoring (TDM) if available

Screening for osteoporosis with bone mineral density testing periodically after diagnosis