Advanced Therapies in Crohn's Disease
TB skin test
Baseline blood work (baseline CBC, renal and liver enzymes, HBV)
Ensure all age appropriate immunizations are current.
Infusion centre
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Adult Dosing
Induction:
200mg IV over one hour at wk 0,4 and 8
Or
400mg SC injection at wk 0, 4 and 8. Each 400mg dose is given as two injections of 200mg
Then maintenance 100mg SC at week 16 and every 8wks thereafter
A dose of 200mg SC at wk 12 and every 4 wks thereafter may be considered for patients who do not show adequate therapeutic benefit or according to clinical judgement.
No dose adjustment is needed in the elderly.
Minimum 1 hour infusion and < 5 min SC injection
Blood work q 3 months including CBC, liver enzymes, lipids, and renal function
Cervical cancer screening – pap test as per provincial guidelines
Annual skin exam – skin malignancies
Influenza vaccine recommended
Screening for osteoporosis with bone mineral density testing periodically after diagnosis