Advanced Therapies in Crohn's Disease
TB skin test
Blood work (baseline CBC, renal and liver function, HBV)
Ensure all immunizations are current.
Wait at least four weeks to start following administration of live vaccination.
Pneumococcal vaccination recommended for adult patients.
Recommend vaccinations HAV, HBV, HPV, and Tdap.
Refer to CANIBD Vaccination Guidelines for further information.12
Use with caution in patients with chronic or recurrent infection.
Liver tests as per routine patient management prior to initiating therapy.
IV infusion x 3 then on-body (SC) injector (OBI) with pre-filled cartridge
Infusion centre
Home
Induction:
600 mg IV at wk 0, wk 4 and wk 8
Then 360 mg subcutaneous (OBI) at wk 12 and every 8 wks thereafter.
Minimum 1 hr infusion
OBI injection <15 min
Cervical cancer screening – pap test as per provincial guidelines
Annual skin exam – skin malignancies
Influenza vaccine recommended
Screening for osteoporosis with bone mineral density testing periodically after diagnosis
Liver enzymes as part of your routine blood work.