Advanced Therapies in Crohn's Disease
Approved for use in paediatric patients.
Data supporting the efficacy of anti-TNF therapy in the elderly is limited with some studies showing similar results in elderly and younger onset IBD and others suggesting lower efficacy.
Caution should be used when treating the elderly.
Data on safety of anti-TNF therapy reports increased rates of adverse events in elderly patients.
Anti-TNF therapy is not suitable for patients with history of either CHF and recent malignancy (< 2 years).
The authors of the 2025 Global Consensus Statement on the Management of Pregnancy in Inflammatory Bowel Disease recommend:13
Women with IBD who are pregnant or attempting conception should continue biosimilar to existing biologics.
In women with IBD who are pregnant or attempting conception, we recommend continuing maintenance anti-TNF therapy throughout pregnancy.
In women with IBD who are pregnant or attempting conception, we suggest continuing maintenance combination therapy with an anti-TNF and thiopurine therapy throughout pregnancy.
In women with inflammatory bowel disease who are pregnant or attempting conception, we suggest continuing maintenance thiopurine therapy as data do not demonstrate an increased risk of congenital malformation or infant infections.
Please refer to the original publication for additional information.13
The authors of the 2025 Global Consensus Statement on the Management of Pregnancy in Inflammatory Bowel Disease recommend: 13
Mothers with IBD currently on anti-TNF agents may breastfeed.
Please refer to the original publication for additional information.13